Shared Genetic Influences on ADHD Symptoms and Very Low-Frequency EEG Activity: A Twin Study

Autor/inn/en	Tye, Charlotte; Rijsdijk, Fruhling; Greven, Corina U.; Kuntsi, Jonna; Asherson, Philip; McLoughlin, Grainne
Titel	Shared Genetic Influences on ADHD Symptoms and Very Low-Frequency EEG Activity: A Twin Study
Quelle	In: Journal of Child Psychology and Psychiatry, 53 (2012) 6, S.706-715 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2011.02501.x
Schlagwörter	Attention Deficit Hyperactivity Disorder; Twins; Genetics; Genetic Disorders; Symptoms (Individual Disorders); Neurological Impairments; At Risk Persons; Comparative Analysis; Structural Equation Models; Cognitive Processes + Suchen Sie Ihr Suchwort? Twin; Zwilling; Humangenetik; Psychiatrische Symptomatik; Neurodegenerative Erkrankung; Risikogruppe; Cognitive process; Kognitiver Prozess
Abstract	Background: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex aetiology. The identification of candidate intermediate phenotypes that are both heritable and genetically linked to ADHD may facilitate the detection of susceptibility genes and elucidate aetiological pathways. Very low-frequency (VLF; less than 0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder. Methods: Direct-current (DC)-EEG was recorded during a cognitive activation condition in 30 monozygotic and dizygotic adolescent twin pairs concordant or discordant for high ADHD symptom scores, and 37 monozygotic and dizygotic matched-control twin pairs with low ADHD symptom scores. Structural equation modelling was used to quantify the genetic and environmental contributions to the phenotypic covariance between ADHD and VLF activity. Results: Attention deficit hyperactivity disorder was significantly associated with reduced VLF power during cognitive activation, which suggests reduced synchronization of widespread neuronal activity. Very low-frequency power demonstrated modest heritability (0.31), and the genetic correlation (-0.80) indicated a substantial degree of overlap in genetic influences on ADHD and VLF activity. Conclusions: Altered VLF activity is a potential candidate intermediate phenotype of ADHD, which warrants further investigation of underlying neurobiological and genetic mechanisms. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10